The Twenty Two New York

Set in the restored Margaret Louisa Vanderbilt house in Flatiron, The Twenty Two New York blends Manhattan history with modern luxury. Interiors nod to classic American design, and its 76 rooms and suites range from swanky entry-level spaces to a singular penthouse. A members’ club atmosphere mixes locals with travelers, complemented by Cafe Zaffri, an all-day restaurant by New York culinary talent.